Ines BLOCKX
Telephone: (+32) 3 265 2786
Fax: (+32) 3 265 2774
Faculty of Pharmaceutical, Veterinary and Biomedical Sciences
Department of Biomedical Sciences
Address
Campus Drie Eiken
D.UC.112
Universiteitsplein 1
2610 Wilrijk
RECENT RESEARCH TOPICS
Huntington’s disease (HD) is a late manifesting neurodegenerative disease caused by the expansion of a CAG repeat in the IT15 huntingtin gene. Transgenic animal models of HD have provided new ways for studying the underlying neuropathological mechanisms of the disease. With the use of a unique transgenic rat model from von Hörsten et al. 2003 (Tübingen, Germany), Ines Blockx performs longitudinal in vivo MRI imaging studies to investigate changes in neuroconnectivity, neuroactivity and neurogenesis in search for early diagnostic and drug evaluation MRI tools.
Publications
- Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment.
Blockx I, De Groof G, Verhoye M, Van Audekerke J, Raber K, Poot D, Sijbers J, Osmand AP, Von Hörsten S, Van der Linden A.
Neuroimage in press - Genotype specific age related changes in a transgenic rat model of Huntington's disease.
I. Blockx, N. Van Camp, M. Verhoye, R. Boisgard, A. Dubois, B. Jego, E. Jonckers, K. Raber, K. Siquier, B. Kuhnast, F. Dollé, H.P. Nguyen, S. Von Hörsten, B. Tavitian, A. Van der Linden.
Neuroimage. 2011 Oct 15;58(4):1006-16. - More accurate estimation of diffusion tensor parameters using diffusion Kurtosis imaging.
J. Veraart, D.H. Poot, W. Van Hecke, I. Blockx, A. Van der Linden, M. Verhoye, J. Sijbers.
Magn Reson Med. 2011 Jan;65(1):138-45.
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Population-averaged diffusion tensor imaging atlas of the Sprague Dawley rat brain.
J. Veraart, T.B. Leergaard, B.T. Antonsen, W. Van Hecke, I. Blockx, B. Jeurissen, Y. Jiang, A. Van der Linden, G.A. Johnson, M. Verhoye, J. Sijbers.
Neuroimage. 2011 Oct 15;58(4):975-83.A complementary diffusion tensor imaging (DTI)-histological study in a model of Huntington's disease.
N. Van Camp, I. Blockx, L. Camón, N. de Vera, M. Verhoye, J. Veraart, W. Van Hecke, E. Martínez, S. Guadalupe, J. Sijbers, A.M. Planas, A. Van der Linden.
Neurobiol Aging.; in press. 2011.Diffusion Tensor Imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract.
N.Van Camp, I. Blockx, M. Verhoye, C. Casteels, F. Coun, A. Leemans, J, Sijbers, V. Baekelandt, K, Van Laere, A. Van der Linden.
NMR Biomed 22:7(2009), p. 697-706.
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