Neurogenesis team
Team
Rationale and Objectives:
The adult mammalian brain displays neurogenesis in two regions (dendate gyrus of hippocampus and the subventricular zone in the lateral ventricles).
We develop in vivo MRI and Bioluminescence imaging tools to localize and quantify neurogenesis and the subsequent stem cell recruitment. These tools are then used to monitor endogeneous stem cell recruitment to the OB as a read out for neurogenesis or to damaged brain regions for repair.
Methodology:
Various in situ MRI contrast labeling strategies for stem cells in the subventricular zone validated with MRI and histology.
Funding
Team
- Annemie Van der Linden (Professor)
- Michiel Vellema (PhD student)
- Jelle Praet (PhD student)
Rationale and Objectives:
The adult mammalian brain displays neurogenesis in two regions (dendate gyrus of hippocampus and the subventricular zone in the lateral ventricles).
We develop in vivo MRI and Bioluminescence imaging tools to localize and quantify neurogenesis and the subsequent stem cell recruitment. These tools are then used to monitor endogeneous stem cell recruitment to the OB as a read out for neurogenesis or to damaged brain regions for repair.
Methodology:
Various in situ MRI contrast labeling strategies for stem cells in the subventricular zone validated with MRI and histology.
Funding
- EC DIMI NoE
- GOA
- IWT (PhD grants)
- IUAP MIMI
- SBO grants in collaboration with C. Verfaillie (KUL)
- Veerle Baekelandt
- Catherine Verfaillie
- Ludwig Aigner
