Small Animal Imaging Core facility Antwerp
Examples of Biomedical Research : animal models of human diseases
1 . Non invasive in vivo neuro imaging for phenotyping (transgenic) mouse or rat models for human neurological diseases outside our main research topics
• FRAGILE X
• HYDROCEPHALUS
• WILLIAMS SYNDROME CLIP
• ALS (Amyotrophic lateral sclerosis)
• STROKE
• MULTIPLE SCLEROSIS
• Brain studies of mouse models for neurogenetic disorders in general
• Non invasive in vivo imaging of tumor perfusion in nude mice.
Figure 1 : 3D reconstruction of the ventricles (red) and cerebellum (purple) from in vivo MRI-data demonstrating anatomical abnormalities of the central nervous system of a transgenic mouse model for Williams Syndrome (left) with respect to a control mouse (right).
Figure 2 : MRI imaging of mice sacroiliac joints was found to be an important tool to monitor axial inflammation in as preclinical models of spondyloarthropathy.
Collaborations on disease models:
Examples of Biomedical Research : animal models of human diseases
1 . Non invasive in vivo neuro imaging for phenotyping (transgenic) mouse or rat models for human neurological diseases outside our main research topics
• FRAGILE X
- Neuroanatomy of the fragile X knockout mouse brain studied using in vivo high resolution magnetic resonance imaging.
- Watershed-based Segmentation of 3D MR Data for Volume Quantization.
- Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI).
• HYDROCEPHALUS
• WILLIAMS SYNDROME CLIP
• ALS (Amyotrophic lateral sclerosis)
• STROKE
- Non invasive in vivo imaging of the brain of rat and mice in different animal disease models with medical relevance such as stroke and MS.
• MULTIPLE SCLEROSIS
- In vivo non-invasive determination of abnormal water diffusion in the rat brain studied in an animal model for multiple sclerosis by diffusion-weighed NMR imaging.
• Brain studies of mouse models for neurogenetic disorders in general
• Non invasive in vivo imaging of tumor perfusion in nude mice.
- Quantification of tumour microvascular permeability in human glioma xenografts using dynamic T1 MRI with Gadomer-17.
- Assessment of the Neovascular Permeability in Glioma Xenografts by Dynamic T1 MRI With Gadomer-17.
Figure 1 : 3D reconstruction of the ventricles (red) and cerebellum (purple) from in vivo MRI-data demonstrating anatomical abnormalities of the central nervous system of a transgenic mouse model for Williams Syndrome (left) with respect to a control mouse (right).
Figure 2 : MRI imaging of mice sacroiliac joints was found to be an important tool to monitor axial inflammation in as preclinical models of spondyloarthropathy.
Collaborations on disease models:
- Human Genetics - Frank Kooy
- Molecular Genetics - Christine Van Broeckhoven
- Laboratory of Neurochemistry and Behavior -Peter De Deyn (Antwerp, Belgium)
- Molecular Cardiovascular Medicine Group - Peter Carmeliet (Leuven, Belgium)
- Experimental Genetics Group - Fred Van Leuven (Leuven, Belgium)
- Reumatologie, UZGent - Dirk Elewaut (Gent, Belgium)
- GIfMI (Ghent Institute for fMRI) - Rik Achten (Gent, Belgium)
- Department of Neuroscience - Chris I. De Zeeuw (Rotterdam, The Netherlands)
- Department of Cell Biology and Genetics - Niels Galjart, (Rotterdam, The Netherlands)
- Experimental biomedical MR research - Arend Heerschap(Nijmegen, The Netherlands)
